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In situ engenharia genética de células T hospedeiras baseada em estratégia de andaime acelular: um passo grande, mas também pequeno, para a imunoterapia de tumores sólidos

  • role： First author第一作者
  • Affiliation：

    Bioscience and Biomedical Engineering Thrust, the Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China

    Department of Nephrology, Center of Kidney and Urology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, Guangdong, China

Shu-Yan Han12,  
  • Affiliation：

    Bioscience and Biomedical Engineering Thrust, the Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China

Zi-Xuan Zhao1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Bioscience and Biomedical Engineering Thrust, the Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China

    Division of Life Science, the Hong Kong University of Science and Technology, Hong Kong 999077, China

  • Email：junwuhkust@ust.hk
  • Introduction：*junwuhkust@ust.hk
Jun Wu13*

Resumo

Palavras-chave

Acellular biomaterial scaffold;T-cell therapy;Solid tumor immunotherapy;Biomaterial-biosystem interaction;Multidisciplinary and interdisciplinary;Clinical transformation

References

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    Zhu C, Wu Q, Sheng T, Shi J, Shen X, Yu J, et al. Rationally designed approaches to augment CAR-T therapy for solid tumor treatment. Bioact Mater. 2024;33:377–95.
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    Liu H, Shen W, Liu W, Yang Z, Yin D, Xiao C. From oncolytic peptides to oncolytic polymers: a new paradigm for oncotherapy. Bioact Mater. 2024;31:206–30.
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    Dandia HY, Pillai MM, Sharma D, Suvarna M, Dalal N, Madhok A, et al. A cellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy. Mil Med Res. 2024;11(1):3.
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    Dagher OK, JrPosey AD. Forks in the road for CAR T and CAR NK cell cancer therapies. Nat Immunol. 2023;24(12):1994–2007.
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    Walsh LA, Quail DF. Decoding the tumor microenvironment with spatial technologies. Nat Immunol. 2023;24(12):1982–93.
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    Liu L, Yoon CW, Yuan Z, Guo T, Qu Y, He P, et al. Cellular and molecular imaging of CAR-T cell-based immunotherapy. Adv Drug Deliv Rev. 2023;203: 115135.

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