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Decifrando a interação molecular e a tumorigênese no carcinoma hepatocelular por meio de insights sobre FBXL6 e KRASG12D

  • role： First author第一作者
  • Affiliation：

    Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China

Qiang Cai1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Institute of Chemistry, University of Silesia in Katowice, 41-500 Chorzów, Poland

  • Email：tanminul-haque-shubra.quazi@us.edu.pl
  • Introduction：*tanminul-haque-shubra.quazi@us.edu.pl; shubhro.du@gmail.com
Quazi T. H. Shubhra2*

Resumo

Palavras-chave

hepatocellular carcinoma;F-box and leucine-rich repeat 6 (FBXL6) activation;Kirsten rat sarcoma (KRAS)G12D mutation;Mitogen-activated protein kinase (MEK)/mammalian target of rapamycin (mTOR) pathway;metastasis

References

  1. 1..
    Xiong HJ, Yu HQ, Zhang J, Fang L, Wu D, Lin XT, et al. Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice. Mil Med Res. 2023;10(1):68.
  2. 2..
    Shubhra QTH. RARRES2’s impact on lipid metabolism in triple-negative breast cancer: a pathway to brain metastasis. Mil Med Res. 2023;10(1):42.
  3. 3..
    Zaman R, Cai X, Shubhra QTH. Hyperthermia-embolization-immunotherapy: a potent trio in advancing cancer treatment. Trends Mol Med. 2023;29(12):976–8.
  4. 4..
    Huang L, Guo Z, Wang F, Fu L. KRAS mutation: from undruggable to druggable in cancer. Signal Transduct Target Ther. 2021;6(1):386.
  5. 5..
    Hua H, Kong Q, Zhang H, Wang J, Luo T, Jiang Y. Targeting mTOR for cancer therapy. J Hematol Oncol. 2019;12(1):71.
  6. 6..
    Guo K, Xiao N, Liu Y, Wang Z, Tóth J, Gyenis J, et al. Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments: opportunities and challenges. Nano Mater Sci. 2022;4(4):295–321.

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