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Aliviando a disfunção mitocondrial na cardiomiopatia diabética através das vias Adipsin e Irak2

  • role： Corresponding author, First author通信作者, 第一作者
  • Affiliation：

    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

  • Email：mabel.cummins@vanderbilt.edu
  • Introduction：*mabel.cummins@vanderbilt.edu
Mabel L. Cummins1*,  
  • Affiliation：

    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

Grace Delmonte1,  
  • Affiliation：

    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

Skylar Wechsler1,  
  • Affiliation：

    Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

Joseph J. Schlesinger2

Resumo

Palavras-chave

Diabetic cardiomyopathy;Mitochondrial function;Lipotoxicity;Cardiomyocytes;Interleukin-1 receptor-associated kinase-like 2 (Irak2);interleukin-1;Protein kinase R

References

  1. 1..
    Chavali V, Tyagi SC, Mishra PK. Predictors and prevention of diabetic cardiomyopathy. Diabetes Metab Syndr Obes. 2013;6:151–60.
  2. 2..
    Jiang MY, Man WR, Zhang XB, Zhang XH, Duan Y, Lin J, et al. Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy. Mil Med Res. 2023;10(1):63.
  3. 3..
    Zheng J, Ma Y, Guo X, Wu J. Immunological characterization of strokeheart syndrome and identification of inflammatory therapeutic targets. Front Immunol. 2023;14:1227104.
  4. 4..
    AlTamimi JZ, BinMowyna MN, AlFaris NA, Alagal RI, El-Kott AF, Al-Farga AM. Fisetin protects against streptozotocin-induced diabetic cardiomyopathy in rats by suppressing fatty acid oxidation and inhibiting protein kinase R. Saudi Pharm J. 2021;29(1):27–42.
  5. 5..
    Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, et al. Pathophysiology and treatment of diabetic cardiomyopathy and heart failure in patients with diabetes mellitus. Int J Mol Sci. 2022;23(7):3587.
  6. 6..
    Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, et al. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism. 2000;49(11):1390–4.
  7. 7..
    Barrière DA, Noll C, Roussy G, Lizotte F, Kessai A, Kirby K, et al. Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications. Sci Rep. 2018;8(1):424.
  8. 8..
    Zhou H, Wang H, Yu M, Schugar RC, Qian W, Tang F, et al. IL-1 induces mitochondrial translocation of Irak2 to suppress oxidative metabolism in adipocytes. Nat Immunol. 2020;21(10):1219–31.
  9. 9..
    Roberts NW, González-Vega M, Berhanu TK, Mull A, García J, Heydemann A. Successful metabolic adaptations leading to the prevention of high fat diet-induced murine cardiac remodeling. Cardiovasc Diabetol. 2015;14:127.

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