Anterior|Próximo

GPR65 como um potencial novo alvo terapêutico para o tratamento da fibrose hepática

  • role： Corresponding author, First author通信作者, 第一作者
  • Affiliation：

    Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA

  • Email：l0gobe01@louisville.edu
  • Introduction：*l0gobe01@louisville.edu
Leila Gobejishvili1*

Resumo

Palavras-chave

Inflammation;fibrosis;G protein coupled receptor 65;macrophages

References

  1. 1..
    Wang S, Friedman SL. Found in translation-fibrosis in metabolic dysfunction-associated steatohepatitis (MASH). Sci Transl Med. 2023;15(716):eadi0759.
  2. 2..
    Zhang K, Zhang MX, Meng XX, Zhu J, Wang JJ, He YF, et al. Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways. Mil Med Res. 2023;10(1):56.
  3. 3..
    Imenez Silva PH, Camara NO, Wagner CA. Role of proton-activated G protein-coupled receptors in pathophysiology. Am J Physiol Cell Physiol. 2022;323(2):C400–14.
  4. 4..
    Takano K, Kasamatsu S, Aoki M, Takahashi Y. Carbon dioxide-induced decrease in extracellular pH enhances the production of extracellular matrix components by upregulating TGF-β1 expression via CREB activation in human dermal fibroblasts. Exp Dermatol. 2023;32(10):1651–62.

Leia o texto completo

The above content is generated by Large Model Translation. The translated content is for reference only. We do not assume any commercial or legal responsibilty for any consequences arising from the use of our website