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Vesículas extracelulares derivadas de células-tronco mesenquimais na cicatrização de feridas na pele: o risco de indução de deriva senescente em terapêuticas baseadas em secretoma

  • role： First author第一作者
  • Affiliation：

    National Medical Research Radiological Center, Obninsk 249036, Russia

    Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk 249031, Russia

Anna Smirnova12,  
  • Affiliation：

    National Medical Research Radiological Center, Obninsk 249036, Russia

Elena Yatsenko1,  
  • Affiliation：

    National Medical Research Radiological Center, Obninsk 249036, Russia

Denis Baranovskii1,  
  • role： Corresponding author通信作者
  • Affiliation：

    National Medical Research Radiological Center, Obninsk 249036, Russia

    Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk 249031, Russia

  • Email：ilya.klabukov@gmail.com
  • Introduction：*ilya.klabukov@gmail.com
Ilya Klabukov12*

Resumo

Palavras-chave

Cell therapy;Inflammaging;Secretome;Senescence

References

  1. 1..
    Ding JY, Chen MJ, Wu LF, Shu GF, Fang SJ, Li ZY, et al. Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges. Mil Med Res. 2023;10(1):36.
  2. 2..
    Kizilay Mancini Ö, Lora M, Shum-Tim D, Nadeau S, Rodier F, Colmegna I. A proinflammatory secretome mediates the impaired immunopotency of human mesenchymal stromal cells in elderly patients with Atherosclerosis. Stem Cells Transl Med. 2017;6(4):1132–40.
  3. 3..
    Zhang Y, Ravikumar M, Ling L, Nurcombe V, Cool SM. Age-related changes in the inflammatory status of human mesenchymal stem cells: implications for cell therapy. Stem Cell Rep. 2021;16(4):694–707.
  4. 4..
    Wu X, Xu X, Xiang Y, Fan D, An Q, Yue G, et al. Exosome-mediated effects and applications in inflammatory diseases of the digestive system. Eur J Med Res. 2022;27(1):163.
  5. 5..
    Lyamina S, Baranovskii D, Kozhevnikova E, Ivanova T, Kalish S, Sadekov T, et al. Mesenchymal stromal cells as a driver of inflammaging. Int J Mol Sci. 2023;24(7):6372.

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