이전|다음

간질 발작 생물물리학: 국소 전압 차이의 역할

  • role： Corresponding author, Contribute equally, First author通信作者, 同等贡献者, 第一作者
  • Affiliation：

    Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China

  • Email：yinkuiying77@outlook.com
  • Introduction：* Kui-Ying Yin yinkuiying77@outlook.com
Kui-Ying Yin1*,  
  • role： Corresponding author, Contribute equally通信作者, 同等贡献者
  • Affiliation：

    Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China

  • Email：yutaoly@sina.com
  • Introduction：Tao Yu yutaoly@sina.com
Tao Yu2*,  
  • Affiliation：

    Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China

Chuan Liu1,  
  • Affiliation：

    Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China

Jin-Rong Yin1

추상적인

배경간질은 과흥분성 신경망 활동으로 인한 반복적 발작을 특징으로 하는 신경학적 장애입니다. 발현은 영향을 받는 뇌 영역과 그 근본 원인에 따라 미묘한 감각 장애부터 의식의 심각한 변화까지 다양합니다. 간질 발작의 생물물리학적 메커니즘을 탐구하는 것은 질병 예측 및 제어에 중요합니다.방법우리는 국소 간질 환자 24명에서 기록된 45건의 자연 발작과 2명의 추가 환자에서 유도된 자극 발작을 분석했습니다. 2차 Butterworth 저역 통과 필터를 사용하여 뇌파에서 종종 간과되는 주파수 범위인 느리게 변하는 직류 성분(Sv DC)(0.01–0.5 Hz)을 분리했습니다. Sv DC 성분의 에너지 비율은 발작 동안 및 발작을 포함한 1시간 동안의 총 에너지 대비 비율로 계산되어 발작 상태와 비발작 상태 간 비교를 가능하게 했습니다.결과Sv DC 성분은 발작기와 비발작기 모두에서 공간적으로 역동적인 변화를 보였으며 고주파 활동과 중간 정도의 상관관계를 보였습니다. 또한 두 기간 모두에서 높은 에너지 비율을 차지했으며, 발작 데이터에서는 80.82%의 리드가 60% 이상의 Sv DC 에너지를 보였습니다. 특히 비발작기 Sv DC 변동은 간질 발생 부위 내 전극에서 더 뚜렷하게 나타나 간질 발생 위치의 마커로서 잠재력을 시사합니다. 더불어 Sv DC 신호의 시간적 변동성은 그 분산에 반영되어 발작 발생의 조기 지표로서 가능성을 보여줍니다.결론Sv DC 성분은 이온 채널 활동과 연관된 국소 전압 차이를 반영할 수 있으며, 발작 시작에 기여할 수 있습니다. 낮은 주파수 및 높은 주파수 성분과의 결합 분석은 간질 네트워크를 이해하고 진단 및 치료를 안내하는 포괄적 프레임워크를 제공합니다.

키워드

간질;간질 발작;느리게 변하는 직류 전기장 (Sv DC);국소 전압 차이;간질 발생 부위

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