종양 휴면과 재발: 암 재발 분자 기전 이해

  • role: First author第一作者
  • Affiliation:

    Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China

Muhammad Tufail1,  
  • Affiliation:

    Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China

    Institute of Oral Precancerous Lesions, Central South University, Changsha 410008, China

    Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha 410008, China

    National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China

Can-Hua Jiang1234,  
  • role: Corresponding author通信作者
  • Affiliation:

    Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China

    Institute of Oral Precancerous Lesions, Central South University, Changsha 410008, China

    Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha 410008, China

    National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China

  • Email:liningoms@csu.edu.cn
  • Introduction:* Ning Li liningoms@csu.edu.cn
Ning Li1234*

추상적인

종양 휴면 현상에 의해 유발되는 암 재발은 종양학에서 극복하기 어려운 도전 과제입니다. 휴면 암세포는 발견 및 치료를 회피할 수 있어 재발로 이어집니다. 이 리뷰는 종양 휴면 및 암 재발에 미치는 영향을 이해하는 것이 시급함을 강조합니다. 주목할 만한 진전에도 불구하고, 휴면의 기전과 재발 예측을 위한 신뢰할 수 있는 바이오마커 부족에 대한 이해에는 아직 큰 공백이 존재합니다. 이 리뷰는 휴면의 세포학적, 혈관신생학적 및 면역학적 측면을 포괄적으로 분석합니다. 또한 휴면 세포를 표적으로 하는 현재 치료 전략, 특히 병용요법과 면역요법을 강조하며, 이는 재발 방지에 유망한 접근법입니다. 이러한 기전을 밝히고 혁신적인 연구 방법론을 제안함으로써, 본 리뷰는 종양 휴면에 대한 이해를 심화시키고 궁극적으로 암 재발 예방과 환자 예후 향상을 위한 보다 효과적인 전략 개발을 촉진하고자 합니다.

키워드

종양 휴면;암 재발;신호 경로;바이오마커;치료 접근법

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