이전|다음

미토콘드리아 복합체 I: 지속적인 미세아교세포 활성화 및 신경염증 유지의 핵심

  • role： First author第一作者
  • Affiliation：

    Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China

Hua Wang1,  
  • Affiliation：

    Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China

Sheng-Yuan Yu2,  
  • Affiliation：

    Department of Biology, University of Copenhagen, 2100 Copenhagen O, Denmark

Sofus Nielsen3,  
  • role： Corresponding author通信作者
  • Affiliation：

    Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

  • Email：wangxing@iccas.ac.cn
  • Introduction：* wangxing@iccas.ac.cn
Xing Wang4*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China

  • Email：zhaoweiwei@sdu.edu.cn
  • Introduction：zhaoweiwei@sdu.edu.cn
Wei-Wei Zhao5*

추상적인

키워드

Mitochondrial complex I;Neuroinflammation;Multiple sclerosis;Reverse electron transport;Microglial activation

References

  1. 1..
    Peruzzotti-Jametti L, Willis CM, Krzak G, Hamel R, Pirvan L, Ionescu RB, et al. Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature. 2024;628(8006):195–203.
  2. 2..
    Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, et al. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell. 2016;167(2):457–70.e13.
  3. 3..
    Deczkowska A, Keren-Shaul H, Weiner A, Colonna M, Schwartz M, Amit I. Disease-associated microglia: a universal immune sensor of neurodegeneration. Cell. 2018;173(5):1073–81.
  4. 4..
    Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner HL, Lassmann H. Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis. Brain. 2017;140(7):1900–13.
  5. 5..
    Billingham LK, Stoolman JS, Vasan K, Rodriguez AE, Poor TA, Szibor M, et al. Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. Nat Immunol. 2022;23(5):692–704.

더 읽기

The above content is generated by Large Model Translation. The translated content is for reference only. We do not assume any commercial or legal responsibilty for any consequences arising from the use of our website