이전|다음

1990년부터 2021년까지 전 세계, 지역 및 국가 수준에서의 지주막하출혈 역학 추세 분석 연구

  • role： Contribute equally, First author同等贡献者, 第一作者
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

Bin Lv1,  
  • role： Contribute equally同等贡献者
  • Affiliation：

    School of Medicine, Nankai University, Tianjin 300071, China

Jin-Xin Lan2,  
  • role： Contribute equally同等贡献者
  • Affiliation：

    Department of Ophthalmology, the Eighth Medical Center, Affiliated to the Senion Department of Ophthalmology, the Third Medical Center, Chinese PLA General Hospital, Beijing 100091, China

Yan-Fang Si3,  
  • Affiliation：

    School of Medicine, Nankai University, Tianjin 300071, China

Yi-Fan Ren2,  
  • Affiliation：

    Department of Internal Medicine, Gucheng County Hospital of Traditional Chinese Medicine, Hengshui, Hebei 253800, China

Ming-Yu Li4,  
  • Affiliation：

    Department of Outpatient, No.13 Cadre Santatorium of Beijing Garrison, Beijing 100393, China

Fang-Fang Guo5,  
  • Affiliation：

    Department of Neurology, Yongchuan Hospital Affiliated of Chongqing Medical University, Chongqing 402160, China

Ge Tang6,  
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

Yang Bian1,  
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

Xiao-Hui Wang1,  
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

Rong-Ju Zhang1,  
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

Zhi-Hua Du1,  
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

Xin-Feng Liu1,  
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

Sheng-Yuan Yu1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

  • Email：tianchenglin@301hospital.com.cn
  • Introduction：* tianchenglin@301hospital.com.cn
Cheng-Lin Tian1*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

  • Email：caoxiangyu301@126.com
  • Introduction：caoxiangyu301@126.com
Xiang-Yu Cao1*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

  • Email：wangjun301@126.com
  • Introduction：wangjun301@126.com
Jun Wang1*

추상적인

Background:Subarachnoid hemorrhage (SAH) is a subtype of hemorrhagic stroke characterized by high mortality and low rates of full recovery. This study aimed to investigate the epidemiological characteristics of SAH between 1990 and 2021.Methods:Data on SAH incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021 were obtained from the Global Burden of Disease Study (GBD) 2021. Estimated annual percentage changes (EAPCs) were calculated to evaluate changes in the age-standardized rate (ASR) of incidence and mortality, as well as trends in SAH burden. The relationship between disease burden and socio-demographic index (SDI) was also analyzed.Results:In 2021, the incidence of SAH was found to be 37.09% higher than that in 1990; however, the age-standardized incidence rates (ASIRs) showed a decreased [EAPC: –1.52; 95% uncertainty interval (UI) –1.66 to –1.37]. Furthermore, both the number and rates of deaths and DALYs decreased over time. It was observed that females had lower rates compared to males. Among all regions, the high-income Asia Pacific region exhibited the highest ASIR (14.09/100,000; 95% UI 12.30/100,000–16.39/100,000) in 2021, with an EPAC for ASIR <0 indicating decreasing trend over time for SAH ASIR. Oceania recorded the highest age-standardized mortality rates (ASMRs) and age-standardized DALYs rates among all regions in 2021 at values of respectively 8.61 (95% UI 6.03–11.95) and 285.62 (95% UI 209.42–379.65). The burden associated with SAH primarily affected individuals aged between 50–69 years old. Metabolic risks particularly elevated systolic blood pressure were identified as the main risk factors contributing towards increased disease burden associated with SAH when compared against environmental or occupational behavioral risks evaluated within the GBD framework.Conclusions:The burden of SAH varies by gender, age group, and geographical region. Although the ASRs have shown a decline over time, the burden of SAH remains significant, especially in regions with middle and low-middle SDI levels. High systolic blood pressure stands out as a key risk factor for SAH. More specific supportive measures are necessary to alleviate the global burden of SAH.

키워드

Subarachnoid hemorrhage (SAH);Global Burden of Disease Study (GBD) 2021;Incidence;Mortality;Disability-adjusted life-years (DALYs)

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