이전|다음

간 섬유증 치료를 위한 잠재적인 새로운 치료 표적으로서의 GPR65

  • role： Corresponding author, First author通信作者, 第一作者
  • Affiliation：

    Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA

  • Email：l0gobe01@louisville.edu
  • Introduction：*l0gobe01@louisville.edu
Leila Gobejishvili1*

추상적인

키워드

Inflammation;fibrosis;G protein coupled receptor 65;macrophages

References

  1. 1..
    Wang S, Friedman SL. Found in translation-fibrosis in metabolic dysfunction-associated steatohepatitis (MASH). Sci Transl Med. 2023;15(716):eadi0759.
  2. 2..
    Zhang K, Zhang MX, Meng XX, Zhu J, Wang JJ, He YF, et al. Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways. Mil Med Res. 2023;10(1):56.
  3. 3..
    Imenez Silva PH, Camara NO, Wagner CA. Role of proton-activated G protein-coupled receptors in pathophysiology. Am J Physiol Cell Physiol. 2022;323(2):C400–14.
  4. 4..
    Takano K, Kasamatsu S, Aoki M, Takahashi Y. Carbon dioxide-induced decrease in extracellular pH enhances the production of extracellular matrix components by upregulating TGF-β1 expression via CREB activation in human dermal fibroblasts. Exp Dermatol. 2023;32(10):1651–62.

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