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てんかん発作の生物物理学：局所電圧差の役割

  • role： Corresponding author, Contribute equally, First author通信作者, 同等贡献者, 第一作者
  • Affiliation：

    Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China

  • Email：yinkuiying77@outlook.com
  • Introduction：* Kui-Ying Yin yinkuiying77@outlook.com
Kui-Ying Yin1*,  
  • role： Corresponding author, Contribute equally通信作者, 同等贡献者
  • Affiliation：

    Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China

  • Email：yutaoly@sina.com
  • Introduction：Tao Yu yutaoly@sina.com
Tao Yu2*,  
  • Affiliation：

    Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China

Chuan Liu1,  
  • Affiliation：

    Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China

Jin-Rong Yin1

サマリー

背景てんかんは、過興奮性神経ネットワーク活動による反復発作を特徴とする神経障害である。発現は影響を受ける脳領域とその基礎病因に応じて、微妙な感覚障害から意識の深刻な変化まで大きく異なる。てんかん発作の生物物理学的メカニズムの探究は、病気の予測と制御に重要である。方法われわれは、焦点性てんかんの24人の患者から記録された45件の自然発作および2人の追加患者からの刺激誘発発作を分析した。2次バターワースローパスフィルターを用いて、脳波でしばしば見落とされる周波数帯域であるゆっくり変動する直流成分（Sv DC）（0.01〜0.5 Hz）を分離した。Sv DC 成分のエネルギー比は、発作中および発作を含む1時間の期間中の総エネルギーに対する比率として計算され、発作時と発作間状態の比較を可能にした。結果Sv DC 成分は、発作時および発作間期の両期間にわたり空間的に動的な変化を示し、高周波活動と中程度の相関を示した。さらに、両期間において高いエネルギー割合を占め、発作データでは80.82％のリードが60％以上のSv DC エネルギーを持つことが示された。注目すべきは、発作間Sv DC の変動がてんかん原性領域内の電極でより顕著であり、てんかん原局定位マーカーとしての可能性を示唆していることである。さらに、Sv DC 信号の時間的変動性は、その分散に反映され、発作発展の早期指標としての可能性を示す。結論Sv DC 成分は、イオンチャネル活動に関連すると思われる局所的な電位差を反映し、発作の開始に寄与する可能性がある。Sv DC を低周波・高周波成分と組み合わせて解析することは、てんかんネットワークの理解と診断および治療の指針となる包括的な枠組みを提供する。

キーワード

てんかん;てんかん発作;ゆっくり変動する直流（Sv DC）場;局所電圧差;てんかん原性領域

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