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ナノザイム駆動型多機能被覆材：慢性創傷治療における酵素様触媒作用を超えて

  • role： Contribute equally, First author同等贡献者, 第一作者
  • Affiliation：

    CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

    College of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China

Si-Jie Zhang12,  
  • role： Contribute equally同等贡献者
  • Affiliation：

    CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

    College of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China

Ran Xu12,  
  • role： Contribute equally同等贡献者
  • Affiliation：

    CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

    Laboratory of Clinical Pharmacy, Department of Pharmacy, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, China

Shao-Bin He13,  
  • Affiliation：

    Department of Radiation Oncology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210000, China

Rong Sun4,  
  • Affiliation：

    Shenyang Key Laboratory of Medical Molecular Theranostic Probes in School of Pharmacy, Shenyang Medical College, Shenyang 110034, China

Guan-Nan Wang5,  
  • Affiliation：

    Peking University People’s Hospital, Beijing 100044, China

Shu-Yi Wei6,  
  • Affiliation：

    CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

    College of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China

    Nanozyme Laboratory in Zhongyuan, Henan Academy of Innovations in Medical Science, Zhengzhou 451163, China

Xi-Yun Yan127,  
  • role： Corresponding author通信作者
  • Affiliation：

    CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

    College of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China

    Nanozyme Laboratory in Zhongyuan, Henan Academy of Innovations in Medical Science, Zhengzhou 451163, China

  • Email：fankelong@ibp.ac.cn
  • Introduction：* Ke-Long Fan fankelong@ibp.ac.cn
Ke-Long Fan127*

サマリー

慢性創傷の治療は、持続的な炎症および生化学的不均衡を特徴とする複雑な微小環境内での治癒促進の必要性のために、重大な課題を呈します。細菌感染、高血糖、および酸化ストレスなどの要因は細胞機能を乱し、血管新生を阻害して創傷修復を大幅に遅延させます。ナノザイムは、酵素様活性を持つ設計されたナノスケール材料であり、従来の酵素や伝統的なナノ材料に比べて明確な利点を提供し、慢性創傷治療の有望な候補となっています。臨床的な可能性を高めるために、ナノザイムベースの触媒システムは、組成の改良や生体適合性、抗酸化活性、抗菌効果、組織修復能力を評価する前臨床研究を通じて最適化されており、安全性と臨床応用性が確保されています。多機能性創傷被覆材に統合されると、ナノザイムは活性酸素種のレベルを調節し、組織再生を促進し、感染と酸化損傷を同時に抑制し、慢性創傷治療における従来の酵素様触媒作用を超えています。ナノザイムのカスタマイズ可能な構造により、複雑な創傷状態の管理において精密な治療応用が可能となり、その効果を高めます。本レビューは、創傷被覆材へのナノザイムの組み込みについて包括的に分析し、製造方法を詳述し、慢性創傷管理におけるその変革的な可能性を強調します。主要な制約を特定し対処することで、ナノザイム駆動型被覆材の開発を促進する戦略的進展を紹介し、次世代の慢性創傷治療への道を開きます。

キーワード

ナノザイム; 酵素様活性; 活性酸素種調節; 慢性創傷療法; 多機能創傷被覆材

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