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幹細胞由来の共移植片はレーザー損傷ラットモデルにおける網膜再建および視覚機能の改善に寄与する

  • role： First author第一作者
  • Affiliation：

    Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA 91030, USA

Deepthi S. Rajendran Nair1,  
  • Affiliation：

    Departments of Physical Medicine and Rehabilitation, Ophthalmology, Anatomy, and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA

    Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA

Magdalene J. Seiler23,  
  • Affiliation：

    Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA 91030, USA

    USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA

Juan Carlos Martinez-Camarillo14,  
  • Affiliation：

    Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA

    Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA

Yuntian Xue35,  
  • Affiliation：

    Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD 20892, USA

Ruchi Sharma6,  
  • Affiliation：

    Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD 20892, USA

Kapil Bharti6,  
  • Affiliation：

    Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA 91030, USA

    USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA

Mark S. Humayun14,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA 91030, USA

    USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA

  • Email：biju.thomas@med.usc.edu
  • Introduction：* Biju B. Thomas biju.thomas@med.usc.edu
Biju B. Thomas14*

サマリー

キーワード

幹細胞ベースの治療;網膜オルガノイド;網膜レーザー損傷;網膜変性疾患;網膜色素上皮;網膜移植;共移植片

References

  1. 1..
    Lin B,McLelland BT,Aramant RB,Thomas BB,Nistor G,Keirstead HS, et al. Retina organoid transplants develop photoreceptors and improve visual function in RCS rats with RPE dysfunction. Invest Ophthalmol Vis Sci.2020;61(11):34.
  2. 2..
    McLelland BT,Lin B,Mathur A,Aramant RB,Thomas BB,Nistor G, et al. Transplanted hESC-derived retina organoid sheets differentiate, integrate, and improve visual function in retinal degenerate rats. Invest Ophthalmol Vis Sci. 2018;59(6):2586-603.
  3. 3..
    Rajendran Nair DS,Zhu D,Sharma R,Martinez Camarillo JC,Bharti K,Hinton DR, et al. Long-term transplant effects of iPSC-RPE monolayer in immunodeficient RCS rats. Cells. 2021;10(11):2951.
  4. 4..
    Thomas BB,Lin B,Martinez-Camarillo JC,Zhu D,McLelland BT,Nistor G, et al. Co-grafts of human embryonic stem cell derived retina organoids and retinal pigment epithelium for retinal reconstruction in immunode-ficient retinal Degenerate Royal College of Surgeons rats. Front Neurosci.2021;15:752958.
  5. 5..
    Gandhi JK,Mano F,Iezzi R,LoBue SA,Holman BH,Fautsch MP, et al. Fibrin hydrogels are safe, degradable scaffolds for sub-retinal implantation. PLoS ONE. 2020;15(1):e0227641.
  6. 6..
    Singh MS,Balmer J,Barnard AR,Aslam SA,Moralli D,Green CM, et al. Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion. Nat Commun.2016;7:13537.

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