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骨恒常性を調節するための中枢神経系および末梢神経系を標的としたメカニズムと潜在的治療法

  • role： First author第一作者
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Tong-Zhou Liang1,  
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Zhe-Yu Jin1,  
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Yue-Jun Lin1,  
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Zi-Yi Chen1,  
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Ye Li1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

    Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

  • Email：jiankunxu@cuhk.edu.hk
  • Introduction：* Jian-Kun Xu jiankunxu@cuhk.edu.hk
Jian-Kun Xu12*,  
  • role： Corresponding author通信作者
  • Affiliation：

    The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, Guangdong, China

  • Email：fan.yang@siat.ac.cn
  • Introduction：Fan Yang fan.yang@siat.ac.cn
Fan Yang3*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

    Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

    Areas of Excellence Centre for Musculoskeletal Degeneration and Regeneration, Sha Tin 999077, Hong Kong, China

  • Email：lingqin@cuhk.edu.hk
  • Introduction：Ling Qin lingqin@cuhk.edu.hk
Ling Qin124*

サマリー

骨格はさまざまな種類の神経によって支配され、神経系からの信号を受け取って恒常性を維持し、再生や修復を促進します。末梢神経およびシグナルの骨恒常性調節における役割は広く調査されてきましたが、中枢神経系と骨の密接な関係はあまり理解されておらず、骨の分野で注目されるテーマとなっています。本レビューでは、神経系と骨代謝の関係を解明する臨床観察および動物実験について論じました。まず、腹内側視床下部、弓状核、視床下部傍室核、偏桃体、青斑核などの特定の脳核と骨恒常性を結びつける機構的研究を検討しました。次に、感覚神経、交感神経、副交感神経などの骨の神経支配特性および神経亜型に焦点を当てました。さらに、これらの神経の分子的特徴および調節機能をまとめました。最後に、神経機能を利用して骨恒常性を改善し骨再生を促進する利用可能な翻訳的アプローチを含めました。したがって、神経筋骨格相互作用の文脈で神経系を考慮することは、骨格の恒常性と修復過程の理解を深め、最終的に将来の臨床応用に利益をもたらします。

キーワード

骨粗鬆症;中枢神経系;脳核;末梢神経線維;骨恒常性

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