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骨再生における神経血管新生促進の戦略

  • role： Contribute equally, First author同等贡献者, 第一作者
  • Affiliation：

    State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China

Xin-Ling Li1,  
  • role： Contribute equally同等贡献者
  • Affiliation：

    State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China

Yu-Qing Zhao1,  
  • role： Contribute equally同等贡献者
  • Affiliation：

    Department of Stomatology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China

Li Miao2,  
  • Affiliation：

    Department of General Surgery, The First Affiliated Hospital of Xi’an Medical University, Xi’an 710077, China

Yan-Xin An3,  
  • Affiliation：

    State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China

Fan Wu1,  
  • Affiliation：

    State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China

Jin-Yu Han1,  
  • Affiliation：

    State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China

Jing-Yuan Han1,  
  • Affiliation：

    Graduate School of Augusta University, Augusta, GA 30912, USA

Franklin R. Tay4,  
  • role： Corresponding author通信作者
  • Affiliation：

    State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China

  • Email：zhaomu1994@126.com
  • Introduction：* Zhao Mu zhaomu1994@126.com
Zhao Mu5*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Stomatology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China

  • Email：jiaoyang1989731@163.com
  • Introduction：Yang Jiao jiaoyang1989731@163.com
Yang Jiao2*,  
  • role： Corresponding author通信作者
  • Affiliation：

    State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China

  • Email：jingwang@fmmu.edu.cn
  • Introduction：Jing Wang jingwang@fmmu.edu.cn
Jing Wang1*

サマリー

骨組織は血管と神経線維との複雑な相互作用に依存しており、どちらも骨格系の多くの生理学的および病理学的プロセスに不可欠です。血管は神経組織や骨組織に必要な酸素や栄養素を供給し、代謝産物を除去します。同時に、神経線維は成長中に血管に先行し、血管新生を促進し、神経伝達物質を分泌して骨細胞に影響を与え骨形成を刺激します。両者の重要な役割にもかかわらず、現行のバイオマテリアルは一般的に骨内血管修復の促進に重点を置いており、神経の寄与を軽視しがちです。骨内血管および神経線維の分布と主な機能を理解することは、効果的な骨組織工学のためのバイオマテリアルの開発に極めて重要です。本レビューはまず、骨内血管および神経線維の解剖学を探り、それらの骨の胚発生、新陳代謝、修復における重要な役割を強調します。過去10年間における骨内神経血管系の促進を目的とした革新的な骨再生戦略を取り上げます。扱う内容は、材料特性（剛性、表面形状、多孔構造、導電性、圧電性）と細胞外生物因子（神経栄養因子、ペプチド、リボ核酸（RNA）、無機イオン、エクソソーム）です。臨床応用の過程で神経血管化材料が直面する主な課題も強調されます。さらに、本レビューは骨組織の自然な治癒過程をより正確に模倣した骨修復材料の製造を目指す将来の研究方向性および潜在的な開発について議論します。本レビューは、新規神経血管化バイオマテリアルの開発およびその臨床応用の促進において、研究者や臨床医にとって貴重な参考資料となるでしょう。実験研究と実用的応用のギャップを埋めることにより、これらの進展は骨欠損の治療を変革し、骨関連疾患患者の生活の質を大幅に向上させる可能性を秘めています。

キーワード

バイオマテリアル;血管;骨;神経;神経血管新生

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