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短時間のサブオービタル宇宙飛行は宇宙飛行士のドーパミンレベルを低下させ、コルチゾール/BDNFを増加させ、促進的な酸化・炎症環境を引き起こします

  • role： First author第一作者
  • Affiliation：

    Department of Biomedical Sciences, University of Padova, 35129 Padua, Italy

Gerardo Bosco1,  
  • Affiliation：

    Italian Air Force Medical Service, 00175 Rome, Italy

Angelo Landolfi2,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Biomedical Sciences, University of Padova, 35129 Padua, Italy

  • Email：tommasoantonio.giacon@studenti.unipd.it
  • Introduction：* Tommaso Antonio Giacon tommasoantonio.giacon@studenti.unipd.it
Tommaso Antonio Giacon1*,  
  • Affiliation：

    Institute of Clinical Physiology, National Research Council (IFC-CNR), 20162 Milan, Italy

Alessandra Vezzoli3,  
  • Affiliation：

    Department of Biomedical Sciences, University of Padova, 35129 Padua, Italy

    Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA

Nazareno Paolocci14,  
  • role： Corresponding author通信作者
  • Affiliation：

    Institute of Clinical Physiology, National Research Council (IFC-CNR), 20162 Milan, Italy

  • Email：simona.mrakicsposta@cnr.it
  • Introduction：Simona Mrakic-Sposta simona.mrakicsposta@cnr.it
Simona Mrakic-Sposta3*

サマリー

キーワード

Suborbital space flight;Oxidative stress and inflammation;Neuroplasticity

References

  1. 1..
    Krittanawong C, Singh NK, Scheuring RA, Urquieta E, Bershad EM, Macaulay TR, et al. Human health during space travel: state-of-the-art review. Cells. 2022;12(1):40.
  2. 2..
    Popova NK, Kulikov AV, Naumenko VS. Spaceflight and brain plasticity:spaceflight effects on regional expression of neurotransmitter systems and neurotrophic factors encoding genes. Neurosci Biobehav Rev.2020;119:396-405.
  3. 3..
    Cobley JN, Fiorello ML, Bailey DM. 13 reasons why the brain is susceptible to oxidative stress. Redox Biol. 2018;15:490-503.
  4. 4..
    Dedovic K, Duchesne A, Andrews J, Engert V, Pruessner JC. The brain and the stress axis: the neural correlates of cortisol regulation in response to stress. Neuroimage. 2009;47(3):864-71.
  5. 5..
    Jones CW, Overbey EG, Lacombe J, Ecker AJ, Meydan C, Ryon K, et al. Molecular and physiological changes in the SpaceX Inspiration4 civilian crew. Nature. 2024;632(8027):1155-64.

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