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AdipsinおよびIrak2経路を介した糖尿病性心筋症におけるミトコンドリア機能障害の軽減

  • role： Corresponding author, First author通信作者, 第一作者
  • Affiliation：

    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

  • Email：mabel.cummins@vanderbilt.edu
  • Introduction：*mabel.cummins@vanderbilt.edu
Mabel L. Cummins1*,  
  • Affiliation：

    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

Grace Delmonte1,  
  • Affiliation：

    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

Skylar Wechsler1,  
  • Affiliation：

    Division of Critical Care Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

Joseph J. Schlesinger2

サマリー

キーワード

Diabetic cardiomyopathy;Mitochondrial function;Lipotoxicity;Cardiomyocytes;Interleukin-1 receptor-associated kinase-like 2 (Irak2);interleukin-1;Protein kinase R

References

  1. 1..
    Chavali V, Tyagi SC, Mishra PK. Predictors and prevention of diabetic cardiomyopathy. Diabetes Metab Syndr Obes. 2013;6:151–60.
  2. 2..
    Jiang MY, Man WR, Zhang XB, Zhang XH, Duan Y, Lin J, et al. Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy. Mil Med Res. 2023;10(1):63.
  3. 3..
    Zheng J, Ma Y, Guo X, Wu J. Immunological characterization of strokeheart syndrome and identification of inflammatory therapeutic targets. Front Immunol. 2023;14:1227104.
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    AlTamimi JZ, BinMowyna MN, AlFaris NA, Alagal RI, El-Kott AF, Al-Farga AM. Fisetin protects against streptozotocin-induced diabetic cardiomyopathy in rats by suppressing fatty acid oxidation and inhibiting protein kinase R. Saudi Pharm J. 2021;29(1):27–42.
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    Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, et al. Pathophysiology and treatment of diabetic cardiomyopathy and heart failure in patients with diabetes mellitus. Int J Mol Sci. 2022;23(7):3587.
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    Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, et al. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism. 2000;49(11):1390–4.
  7. 7..
    Barrière DA, Noll C, Roussy G, Lizotte F, Kessai A, Kirby K, et al. Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications. Sci Rep. 2018;8(1):424.
  8. 8..
    Zhou H, Wang H, Yu M, Schugar RC, Qian W, Tang F, et al. IL-1 induces mitochondrial translocation of Irak2 to suppress oxidative metabolism in adipocytes. Nat Immunol. 2020;21(10):1219–31.
  9. 9..
    Roberts NW, González-Vega M, Berhanu TK, Mull A, García J, Heydemann A. Successful metabolic adaptations leading to the prevention of high fat diet-induced murine cardiac remodeling. Cardiovasc Diabetol. 2015;14:127.

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