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身体運動は非小細胞肺がんにおいてSQLEを阻害することにより免疫的に寒冷な腫瘍微小環境を逆転させる

  • role： First author第一作者
  • Affiliation：

    Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China

  • Introduction：Zhi-Wen Luo, Ya-Ying Sun, and Wei Xia contributed equally to this work
Zhi-Wen Luo1,  
  • Affiliation：

    Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China

    Department of Sports Medicine, Shanghai General Hospital, Shanghai 200080, China

  • Introduction：Zhi-Wen Luo, Ya-Ying Sun, and Wei Xia contributed equally to this work
Ya-Ying Sun12,  
  • Affiliation：

    Department of Critical Care Medicine, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, Jiangsu, China

  • Introduction：Zhi-Wen Luo, Ya-Ying Sun, and Wei Xia contributed equally to this work
Wei Xia3,  
  • Affiliation：

    Department of Oncology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, Jiangsu, China

Jun-Ying Xu4,  
  • Affiliation：

    Department of Oncology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, Jiangsu, China

Dong-Jing Xie4,  
  • Affiliation：

    Guangdong Pharmaceutical University, Guangzhou 510006, China

Chun-Meng Jiao5,  
  • Affiliation：

    Department of Sports Medicine, Shanghai General Hospital, Shanghai 200080, China

Ji-Ze Dong2,  
  • Affiliation：

    Institute of Acupuncture Research, Institutes of Integrative Medicine, Fudan University, Shanghai 200433, China

Hui Chen6,  
  • Affiliation：

    Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China

Ren-Wen Wan1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China

  • Email：cshiyi@163.com
  • Introduction：*cshiyi@163.com;
Shi-Yi Chen1*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Oncology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, Jiangsu, China

  • Email：meijie1996@njmu.edu.cn
  • Introduction：meijie1996@njmu.edu.cn;
Jie Mei4*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Cardiothoracic Surgery, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214023, Jiangsu, China

  • Email：maowenjun1@njmu.edu.cn
  • Introduction：maowenjun1@njmu.edu.cn
Wen-Jun Mao7*

サマリー

キーワード

Physical exercise;Non-small cell lung cancer (NSCLC);Squalene epoxidase (SQLE);Tumor immune microenvironment (TIME)

References

  1. 1..
    Kurz E, Hirsch CA, Dalton T, Shadaloey SA, Khodadadi-Jamayran A, Miller G, et al. Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell. 2022;40(7):720-37.e5.
  2. 2..
    Rundqvist H, Velica P, Barbieri L, Gameiro PA, Bargiela D, Gojkovic M, et al. Cytotoxic T-cells mediate exercise-induced reductions in tumor growth. Elife. 2020;9:e59996.
  3. 3..
    Muscella A, Stefano E, Marsigliante S. The effects of exercise training on lipid metabolism and coronary heart disease. Am J Physiol Heart Circ Physiol. 2020;319(1):H76–88.
  4. 4..
    Gyamfi J, Kim J, Choi J. Cancer as a metabolic disorder. Int J Mol Sci. 2022;23(3):1155.
  5. 5..
    Mao W, Cai Y, Chen D, Jiang G, Xu Y, Chen R, et al. Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non-small cell lung cancer. JCI Insight. 2022;7(18):e161940.

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