RNA as a genome architect: G-loops in G-quadruplex regulation

Jie Wang; Zhao-Jie Lyu; Qi Zhang; William C. Cho; De-Chao Feng

doi:10.1186/s40779-025-00683-3

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RNA as a genome architect: G-loops in G-quadruplex regulation

COMMENTARY | Updated：2026-01-29

- RNA as a genome architect: G-loops in G-quadruplex regulation
- “In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.”
- Military Medical Research Vol. 12, (2025)
- Affiliations：
  
  1.Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou 310014, China
  2.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
  3.Department of Urology, Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangzhou 518036, China
  4.Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China
  5.Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK
- Author bio：
  
  * William C. Cho chocs@ha.org.hk
  De-Chao Feng dechao.feng@ucl.ac.uk
- Funds：
- DOI：10.1186/s40779-025-00683-3
  CLC：
- Received：26 October 2025，
  
  Accepted：10 December 2025，
  
  Online First：14 January 2026，
  
  Published：2025
- Accepted：
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Jie Wang, Zhao-Jie Lyu, Qi Zhang, et al. RNA as a genome architect: G-loops in G-quadruplex regulation[J/OL]. Military Medical Research, 2025, 12.
DOI：

Jie Wang, Zhao-Jie Lyu, Qi Zhang, et al. RNA as a genome architect: G-loops in G-quadruplex regulation[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00683-3.

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RNA as a genome architect: G-loops in G-quadruplex regulation

DOI：10.1186/s40779-025-00683-3