Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects

Xiu-Ming Zhang; Tian-Hong Gao; Qiu-Yu Cai; Jia-Bin Xia; Yu-Ning Sun; Jian Yang; Wei-Han Li; Sheng-Xu-Ming Zhang; Heng-Rui Lou; Xiao-Tian Yu; Kai-Wen Hu; Jing-Wen Ye; Jin-Xing Zhang; Jie Lei; Le-Chao Cheng; Lin-Jie Xu; Qing Chen; He-Xiang Wang; Mei-Fu Gan; Cheng Lu; Nan Pu; Ming-Li Song; Xin Chen; Wen-Jie Liang; Han Lv; Chao-Qing Xu; Zai-Yi Liu; Jing Zhang; Kai Yan; Zun-Lei Feng

doi:10.1186/s40779-025-00680-6

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Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects

REVIEW | Updated：2026-08-20

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- Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects
- Xiu-Ming Zhang , Tian-Hong Gao , Qiu-Yu Cai , Jia-Bin Xia , Yu-Ning Sun , Jian Yang , Wei-Han Li , Sheng-Xu-Ming Zhang , Heng-Rui Lou , Xiao-Tian Yu , Kai-Wen Hu , Jing-Wen Ye , Jin-Xing Zhang , Jie Lei , Le-Chao Cheng , Lin-Jie Xu , Qing Chen , He-Xiang Wang , Mei-Fu Gan , Cheng Lu , Nan Pu , Ming-Li Song , Xin Chen , Wen-Jie Liang , Han Lv , Chao-Qing Xu , Zai-Yi Liu , Jing Zhang , Kai Yan , Zun-Lei Feng
- Military Medical Research Vol. 13, Issue 6, Pages: 991-1029(2026)
- Affiliations：
  Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
  School of Software Technology, Zhejiang University, Hangzhou 310000, China
  State Key Laboratory of Blockchain and Data Security, Zhejiang University, Hangzhou 310000, China
  Department of Electrical and Computer Engineering, National University of Singapore, Singapore 119077, Singapore
  Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210000, China
  College of Computer Science, Zhejiang University of Technology, Hangzhou 310000, China
  School of Computer and Information, Hefei University of Technology, Hefei 230000, China
  Department of Radiology,the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China
  Department of Pathology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou 318000, Zhejiang, China
  Department of Radiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510000, China
  The Department of Information Engineering and Computer Science, University of Trento, 38123 Trento, Italy
  School of Computer and Computing Science, Hangzhou City University, Hangzhou 310000, China
  Department of Radiology, School of Medicine, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou 510000, China
  Department of Radiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China
  Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100000, China
  Department of Neonatology, Children Hospital of Fudan University, Shanghai 201102, China
- Author bio：
  * Chao-Qing Xu xucq@hzcu.edu.cn
  Zai-Yi Liu liuzaiyi@gdph.org.cn
  Jing Zhang jzhang1989@zju.edu.cn
  Kai Yan fhyankai@gmail.com
  Zun-Lei Feng zunleifeng@zju.edu.cn
- Funds：
- DOI： 10.1186/s40779-025-00680-6
  CLC：
- Accepted：26 November 2025 ，
- Accepted：
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Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects

DOI： 10.1186/s40779-025-00680-6

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