The "cytokine storm" in infection and sepsis:win the battle but lose the war

Jiang-Bo Fan; Qin-Yuan Li; Xi-Feng Feng; Si-Yuan Huang; Rui Wang; Feng-Ying Liao; Di Liu; Wen-Yi Liu; Jian-Hui Sun; Hua-Cai Zhang; Hui-Ting Zhou; Jian-Xin Jiang; Zhen Wang; Ling Zeng

doi:10.1186/s40779-025-00678-0

Your Location：

Home >

Browse articles >

The "cytokine storm" in infection and sepsis:win the battle but lose the war

REVIEW | Updated：2026-01-29

- The "cytokine storm" in infection and sepsis:win the battle but lose the war
- “Cytokine storms, a life-threatening systemic inflammatory syndrome, are the primary driver of multiorgan failure in various clinical situations. This review focuses on cytokine storms triggered by severe infections such as viral pneumonia and bacterial sepsis, exploring the underlying mechanisms and potential therapeutic interventions. Expert xx established the xx system, which provides solutions to solve xx problems.”
- Military Medical Research Vol. 12, (2025)
- Affiliations：
  
  1.Department of Trauma Medical Center, Daping Hospital, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing 400042, China
  2.Department of Respiratory Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents’Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing 400014, China
  3.Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou 215025, Jiangsu, China
  4.Department of Critical Care Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China
- Author bio：
  
  * Jian-Xin Jiang hellojjx@tmmu.edu.cn
  Zhen Wang dpicuwz@tmmu.edu.cn
  Ling Zeng zengling_1025@tmmu.edu.cn
- Funds：
- DOI：10.1186/s40779-025-00678-0
  CLC：
- Received：18 August 2025，
  
  Accepted：24 November 2025，
  
  Online First：12 January 2026，
  
  Published：2025
- Accepted：
Scan QR Code
Jiang-Bo Fan, Qin-Yuan Li, Xi-Feng Feng, et al. The "cytokine storm" in infection and sepsis:win the battle but lose the war[J/OL]. Military Medical Research, 2025, 12.
DOI：

Jiang-Bo Fan, Qin-Yuan Li, Xi-Feng Feng, et al. The "cytokine storm" in infection and sepsis:win the battle but lose the war[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00678-0.

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Better therapy for combat injury

Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction

Sepsis in burns: lessons learned, challenges remain

Cell-free DNA in sepsis: from molecular insights to clinical management

The emerging role of ferroptosis in the pathological development and progression of sepsis

Related Author

Yong-Ming Yao

Hui Zhang

Ting Gong

You-Tan Liu

Jie Fan

Folke Sjöberg

David Greenhalgh

Moustafa Elmasry

Related Institution

Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Fucheng Road 51, Haidian District

Department of Surgery, University of Pittsburgh School of Medicine

Department of Anesthesiology, Shenzhen Hospital, Southern Medical University

Research and Development, Veterans Affairs Pittsburgh Healthcare System

Department of Immunology, University of Pittsburgh School of Medicine

⁰

The "cytokine storm" in infection and sepsis:win the battle but lose the war

DOI：10.1186/s40779-025-00678-0