Diverging global incidence trends of early-onset cancers: comparisons with incidence trends of later-onset cancers and mortality trends of early-onset cancers

Miyu Terashima; Kota Nakayama; Sora Shirai; Satoko Ugai; Hwa-Young Lee; Haruna Matsui; Hiroki Mizuno; Shiori Tanaka; Minkyo Song; Naoko Sasamoto; Ichiro Kawachi; Edward L. Giovannucci; Tomotaka Ugai

doi:10.1186/s40779-025-00670-8

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Diverging global incidence trends of early-onset cancers: comparisons with incidence trends of later-onset cancers and mortality trends of early-onset cancers

RESEARCH | Updated：2026-08-20

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- Diverging global incidence trends of early-onset cancers: comparisons with incidence trends of later-onset cancers and mortality trends of early-onset cancers
- Miyu Terashima , Kota Nakayama , Sora Shirai , Satoko Ugai , Hwa-Young Lee , Haruna Matsui , Hiroki Mizuno , Shiori Tanaka , Minkyo Song , Naoko Sasamoto , Ichiro Kawachi , Edward L. Giovannucci , Tomotaka Ugai
- Military Medical Research Vol. 13, Issue 6, Pages: 869-880(2026)
- Affiliations：
  Division of Integrative Cancer Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan
  Present Address: Okayama University Medical School, Okayama 700-8558, Japan
  Present Address: Depart-ment of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA 02215, USA
  Present Address: Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
  Present Address: Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA
  Graduate School of Public Health and Healthcare Management, the Catholic University of Korea, Seoul 06591, Republic of Korea
  Present Address: Catholic Institute for Public Health and Healthcare Management, the Catholic University of Korea, Seoul 06591, Republic of Korea
  Division of Prevention, Institute for Cancer Control, National Cancer Center, Tokyo 104-0045, Japan
  Labora-tory of Epidemiology and Population Sciences, National Institute On Aging, National Institutes of Health, Baltimore, MD 21224, USA
  Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA
  Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA
  Department of Pathology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115, USA
  Zhu Family Center for Global Cancer Prevention, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA
- Author bio：
  * Tomotaka Ugai tugai@hsph.harvard.edu
- Funds：
- DOI： 10.1186/s40779-025-00670-8
  CLC：
- Accepted：03 November 2025 ，
- Accepted：
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Diverging global incidence trends of early-onset cancers: comparisons with incidence trends of later-onset cancers and mortality trends of early-onset cancers

DOI： 10.1186/s40779-025-00670-8

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摘要

Abstract

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