Neurogenic organ dysfunction syndrome after acute brain injury

Heng Zhang; Wen-Jin Chen; Yan-Gong Chao; Nan Su; Chiara Robba; Marek Czosnyka; Peter Smielewski; Zofia Czosnyka; Wei He; Xiao Hu; De-Zhong Yao; Cheng-Gong Hu; Min Zhou; Yun-Jie Wang; Xiao-Chun Ma; Xiu-Yun Liu; Dong Ming

doi:10.1186/s40779-025-00662-8

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Neurogenic organ dysfunction syndrome after acute brain injury

PERSPECTIVE | Updated：2026-06-10

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- Neurogenic organ dysfunction syndrome after acute brain injury
- “Researchers introduced the novel term neurogenic organ dysfunction syndrome (NODS) to characterize systemic instability after acute brain injury. They explored NODS mechanisms from complex brain network theory, focusing on the central autonomic system's structural network and the central stress system's functional network. This provides solutions for early detection and prevention of complications, improving patient outcomes.”
- Heng Zhang , Wen-Jin Chen , Yan-Gong Chao , Nan Su , Chiara Robba , Marek Czosnyka , Peter Smielewski , Zofia Czosnyka , Wei He , Xiao Hu , De-Zhong Yao , Cheng-Gong Hu , Min Zhou , Yun-Jie Wang , Xiao-Chun Ma , Xiu-Yun Liu , Dong Ming
- Military Medical Research Vol. 13, Issue 4, Pages: 542-558(2026)
- Affiliations：
  1.Department of Neurosurgery, the First Hospital of China Medical University, Shenyang 110001, China
  2.Department of Neurosurgery, Neuroscience ICU, Xuanwu Hospital Capital Medical University, Beijing 100032, China
  3.Depart-ment of Critical Care Medicine, the First Hospital of Tsinghua University, Beijing 100016, China
  4.State Key Laboratory of Advanced Medical Materials and Devices, School of Medicine, Tianjin University, Tianjin 300072, China
  5.IRCCS for Oncology and Neuroscience, San Martino Policlinico Hospital, 16132 Genoa, Italy
  6.Department of Clinical Neurosciences, University of Cambridge, Cambridge CB1 0QQ, UK
  7.Department of Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
  8.Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA 30322, USA
  9.Ministry of Education Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology, Chengdu 611731, China
  10.Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
  11.Department of Critical Care Medicine, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230001, China
  12.Department of Critical Care Medicine, the First Hospital of China Medical University, Shenyang 110001, China
  13.Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin 300380, China
  14.School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
- Author bio：
  * Yun-Jie Wang 19721015@cmu.edu.cn
  Xiao-Chun Ma xcma2972@cmu.edu.cn
  Xiu-Yun Liu xiuyun_liu@tju.edu.cn
  Dong Ming richardming@tju.edu.cn
- Funds：
- DOI： 10.1186/s40779-025-00662-8
  CLC：
- Accepted：26 October 2025 ，
- Accepted：
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Neurogenic organ dysfunction syndrome after acute brain injury

DOI： 10.1186/s40779-025-00662-8

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