Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

Shuang-Qing Wang; Ming-Ji Jin; Ze-Ke Guo; Dong-Ri Shen; Li-Na Jin; Fang Cheng; Yan-Ru Zhao; Teng Liu; Yu-Cai Li; Nuo-Ya Wang; Ling-Qing Chen; Wei Huang; Xiu-Quan Quan; Zhong-Gao Gao

doi:10.1186/s40779-025-00658-4

Your Location：

Home >

Browse articles >

Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

RESEARCH | Updated：2026-06-10

- Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry
- Military Medical Research Vol. 13, Issue 4, Pages: 559-587(2026)
- Affiliations：
  
  1.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sci-ences and Peking Union Medical College, Beijing 100050, China
  2.Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  3.Langfang Kangbao Huitai Biotechnology Co. Ltd, Langfang 065001, Hebei, China
  4.Lan-Jayeon Medical Device Co., Ltd, Beijing 100050, China
  5.Emergency Depart-ment, Yanbian University Hospital, Yanji, Jilin 133000, China
- Author bio：
  
  * Zhong-Gao Gao zggao@imm.ac.cn
- Funds：
- DOI：10.1186/s40779-025-00658-4
  CLC：
- Received：12 May 2025，
  
  Accepted：02 October 2025，
  
  Online First：28 October 2025，
  
  Published：2026-04
- Accepted：
Scan QR Code
Shuang-Qing Wang, Ming-Ji Jin, Ze-Ke Guo, et al. Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry[J]. Military Medical Research, 2026, 13(4): 559-587.
DOI：

Shuang-Qing Wang, Ming-Ji Jin, Ze-Ke Guo, et al. Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry[J]. Military Medical Research, 2026, 13(4): 559-587. DOI： 10.1186/s40779-025-00658-4.

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Engineered exosomes for diabetic foot ulcers: lessons learned, challenges remain

White-light-induced synthesis of injectable alginate- based composite hydrogels for rapid hemostasis

The "cytokine storm" in infection and sepsis:win the battle but lose the war

A methodological guideline for consciousness assessment via neural electrophysiological activity

Cell-free DNA in sepsis: from molecular insights to clinical management

Related Author

Hyun-Do Jung

Xing Huang

Xiao-Bing Fu

Sha Huang

Meng-De Zhang

Zhao Li

Wei Song

Yi Kong

Related Institution

Division of Materials Science and Engineering, Hanyang University

Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, Chinese PLA General Hospital and Chinese PLA Medical College

Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences

⁰

Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

DOI：10.1186/s40779-025-00658-4