Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration

Kirsten Haastert-Talini; Katherina Katsirntaki; Svenja Kankowski; Alexander Kaltenborn; Falk von Lübken; Christine Falk; Christopher Werlein; Danny Jonigk; Arjang Ruhparwar; Bettina Wiegmann

doi:10.1186/s40779-025-00656-6

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Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration

RESEARCH | Updated：2026-06-10

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- Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration
- “Researchers developed an ex vivo limb perfusion system extending limb viability for replantation, establishing a pro-regenerative environment for Wallerian degeneration while omitting anti-inflammatory methylprednisolone amplifies nerve regeneration potential, laying a foundation for the construction of improved amputation care systems.”
- Kirsten Haastert-Talini , Katherina Katsirntaki , Svenja Kankowski , Alexander Kaltenborn , Falk von Lübken , Christine Falk , Christopher Werlein , Danny Jonigk , Arjang Ruhparwar , Bettina Wiegmann
- Military Medical Research Vol. 13, Issue 4, Pages: 588-605(2026)
- Affiliations：
  1.Hannover Medical School, Institute of Neuroanatomy and Cell Biology, 30625 Hannover, Germany
  2.Center for Systems Neuroscience (ZSN), 30625 Hannover, Germany
  3.Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany
  4.Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), 30625 Hannover, Germany
  5.Department of Trauma and Orthopedic Surgery, Plastic, Hand and Reconstructive Surgery, Armed Forces Hospital Westerstede, 26655 Westerstede, Germany
  6.Hannover Medi-cal School, Institute of Transplant Immunology, 30625 Hannover, Germany
  7.German Center for Lung Research (DZL), BREATH Hannover, 30625 Hannover, Germany
  8.Aachen University Medical Center, Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
  9.Hannover Medical School, Institute of Pathology, 30625 Hannover, Germany
- Author bio：
  * Bettina Wiegmann Wiegmann.Bettina@mh-hannover.de
- Funds：
- DOI： 10.1186/s40779-025-00656-6
  CLC：
- Accepted：28 September 2025 ，
- Accepted：
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Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration

DOI： 10.1186/s40779-025-00656-6

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