Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior

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Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior

RESEARCH | Updated：2026-05-08

- Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior
- Ya-Qiao Li , Zhi-Yu Kuang , Bao-Yuan Zhang , Yan-Zhong Hao , Ling-Xiao Li , Jing-Xuan Zhang , Ya-Fan Xiao , Bo-Wen Zhang , Xian-Bao Shi , Xiao-Hui Pu , Zhong-Gui He , Bing-Jun Sun
- Military Medical Research Vol. 13, Issue 3, Pages: 385-399(2026)
- Affiliations：
  1.Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
  2.Department of Bioengineering, Graduate School of Engineering, the University of Tokyo, Tokyo 113-0033, Japan
  3.Department of Pharmacy, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, Liaoning, China
  4.State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, Henan, China
  5.Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, China
- Author bio：
  * Zhong-Gui He hezhonggui@syphu.edu.cn
  Bing-Jun Sun sunbingjun@syphu.edu.cn
- Funds：
- DOI： 10.1186/s40779-025-00648-6
  CLC：
- Accepted：08 September 2025 ，
- Accepted：
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