ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases

Yu Duan; Ze-Chen Shan; Jiao-Jiao Pang; Yu-Guo Chen

doi:10.1186/s40779-025-00646-8

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ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases

REVIEW | Updated：2026-03-26

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- ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases
- “A new review introduces research progress in the field of aldehyde dehydrogenase 2 (ALDH2). Experts explored the regulatory mechanisms through which ALDH2 affects autophagy and cell death pathways, providing a novel theoretical framework for human disease treatment.”
- Yu Duan , Ze-Chen Shan , Jiao-Jiao Pang , Yu-Guo Chen
- Military Medical Research Vol. 13, Issue 2, Pages: 239-266(2026)
- Affiliations：
  1.Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan 250000, China
  2.Chest Pain Center, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan 250000, China
  3.Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan 250000, China
  4.The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan 250000, China
- Author bio：
  * Jiao-Jiao Pang jiaojiaopang@email.sdu.edu.cn
  Yu-Guo Chen chen919085@sdu.edu.cn
- Funds：
- DOI： 10.1186/s40779-025-00646-8
  CLC：
- Accepted：28 August 2025 ，
- Accepted：
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ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases

DOI： 10.1186/s40779-025-00646-8

AI Introduction

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Figs( 6 ) Tabs( 4 )

References

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