Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning

Huai-Jian Jin; Peng Lin; Xiao-Yuan Ma; Sha Huang; Liang Zhang; Ou Hu; Yang-Yang Li; Ying-Bo Wang; Jun Zhu; Bo Hu; Jun-Gang Pu; Qin Qin; Pu-Lin Yan; Bing Liu; Yu Lan; Lin Chen; Yang-Li Xie; Jian He; Yi-Bo Gan; Peng Liu

doi:10.1186/s40779-025-00637-9

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Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning

RESEARCH | Updated：2026-03-26

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- Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning
- “A new study introduces significant research progress in the field of lumbar disc degeneration (LDD). Experts identified four distinct molecular subtypes of LDD using clinical features. This breakthrough could facilitate precise diagnostics and guide personalized treatment strategies for LDD.”
- Huai-Jian Jin , Peng Lin , Xiao-Yuan Ma , Sha Huang , Liang Zhang , Ou Hu , Yang-Yang Li , Ying-Bo Wang , Jun Zhu , Bo Hu , Jun-Gang Pu , Qin Qin , Pu-Lin Yan , Bing Liu , Yu Lan , Lin Chen , Yang-Li Xie , Jian He , Yi-Bo Gan , Peng Liu
- Military Medical Research Vol. 13, Issue 1, Pages: 58-77(2026)
- Affiliations：
  1.Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China
  2.Department of Wound Infection and Drug, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China
  3.Pain Department, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China
  4.State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Senior Department of Hematology, Fifth Medical Center, Medical Innovation Research Department, Chinese PLA General Hospital, Beijing 100071, China
  5.State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, China
  6.Center of Bone Metabolism and Repair, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Laboratory for the Prevention and Rehabilitation of Military Training Related Injuries, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China
  7.Tissue Stress Injury and Functional Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, Chengdu 610031, China
- Author bio：
  * Jian He jianhe.amms@gmail.com
  Yi-Bo Gan ganyibo@tmmu.edu.cn
  Peng Liu liupengd@tmmu.edu.cn
- Funds：
- DOI： 10.1186/s40779-025-00637-9
  CLC：
- Accepted：26 July 2025 ，
- Accepted：
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Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning

DOI： 10.1186/s40779-025-00637-9

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