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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
RESEARCH | Updated：2026-03-26
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    • Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

    • “A new study explores the role of IL-33 in repetitive mild traumatic brain injury (rmTBI). Researchers used an rmTBI mouse model to investigate how IL-33 affects cognitive function and neuroinflammation. The study found that IL-33 enhances microglial phagocytosis and reduces neuronal damage, suggesting it could be a therapeutic target for improving neurological outcomes in rmTBI.”
    • Ze-Xi Jia , Meng-Tian Guo , Mei-Mei Li , Pan Liao , Bo Yan , Wei Zhang , Fang-Yuan Cheng , Ya-Ru Liu , Zi-Han Zhang , Cheng Wei , Jie Zhou , Fang-Lian Chen , Ping Lei , Xin-Tong Ge
    • Military Medical Research Vol. 13, Issue 1, Pages: 24-42(2026)

    • DOI： 10.1186/s40779-025-00631-1     

      CLC：

    • Accepted：16 July 2025 ，

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