Advancements in understanding tumor-resident bacteria and their application in cancer therapy

Yi-Chen Luo; Xiu-Ting Huang; Rui Wang; Yu-Jing Lin; Jia-Xin Sun; Ke-Feng Li; De-Yun Wang; Yan Yan; Yong-Kang Qiao

doi:10.1186/s40779-025-00623-1

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Advancements in understanding tumor-resident bacteria and their application in cancer therapy

REVIEW | Updated：2026-01-27

- Advancements in understanding tumor-resident bacteria and their application in cancer therapy
- “Recent advances in next-generation sequencing and bioinformatics have driven growing interest in the distinct roles of intratumoral microbiota, particularly intracellular bacteria, during tumor evolution. The present review explores the sources, mechanisms of invasion into cancer cells, and potential survival strategies of intracellular bacteria in neoplasms, highlighting their critical role in cancer development. Expert xx established the xx system, which provides solutions to solve xx problems and lay a foundation for the construction of xx system.”
- Military Medical Research Vol. 12, Issue 12, Pages: 1941-1983(2025)
- Affiliations：
  
  1.Centre for Biological Science and Technology, Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Department of Biology, Faculty of Arts and Sciences, Guangdong Zhuhai-Macao Joint Biotech Laboratory, Beijing Normal University, Zhuhai 519087, Guangdong, China
  2.Department of Pathology, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, Guangdong, China
  3.Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai 519000, Guangdong, China
  4.School of Medicine, Sun Yat-Sen University, Shenzhen 518055, Guangdong, China
  5.Faculty of Applied Sciences, Macao Polytechnic University, Macau SAR 999078, China
  6.Department of Otolaryngology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 119228, Singapore
- Author bio：
  
  * Yong-Kang Qiao ykqiao@bnu.edu.cn
- Funds：
- DOI：10.1186/s40779-025-00623-1
  CLC：
- Received：05 September 2024，
  
  Accepted：01 July 2025，
  
  Online First：25 July 2025，
  
  Published：2025-12
- Accepted：
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Yi-Chen Luo, Xiu-Ting Huang, Rui Wang, et al. Advancements in understanding tumor-resident bacteria and their application in cancer therapy[J]. Military Medical Research, 2025, 12(12): 1941-1983.
DOI：

Yi-Chen Luo, Xiu-Ting Huang, Rui Wang, et al. Advancements in understanding tumor-resident bacteria and their application in cancer therapy[J]. Military Medical Research, 2025, 12(12): 1941-1983. DOI： 10.1186/s40779-025-00623-1.

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Advancements in understanding tumor-resident bacteria and their application in cancer therapy

DOI：10.1186/s40779-025-00623-1