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Epileptic seizure biophysics: the role of local voltage difference
RESEARCH | Updated:2026-01-27
    • Epileptic seizure biophysics: the role of local voltage difference

    • Reporting on the latest research in epilepsy, a neurological disorder marked by recurrent seizures, experts have delved into the bio-physical mechanisms of epileptic seizures. By analyzing spontaneous and stimulation-induced seizures from patients with focal epilepsy, they isolated the slow-varying direct current (Sv DC) component, a frequency range often overlooked in electroencephalography. This component, which accounts for a high energy proportion in both ictal and interictal states, showed spatially dynamic changes and a moderate correlation with high-frequency activity. Notably, interictal Sv DC fluctuations were more pronounced in electrodes within the epileptogenic zone, suggesting its potential as a marker for epileptogenic localization. The temporal variability of the Sv DC signal also demonstrates potential as an early indicator of seizure development. This research provides a comprehensive framework for understanding epileptic networks and guiding diagnosis and therapy.
    • Military Medical Research   Vol. 12, Issue 12, Pages: 1845-1859(2025)
    • DOI:10.1186/s40779-025-00620-4    

      CLC:
    • Received:01 November 2024

      Accepted:11 June 2025

      Online First:11 July 2025

      Published:2025-12

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  • Kui-Ying Yin, Tao Yu, Chuan Liu, et al. Epileptic seizure biophysics: the role of local voltage difference[J]. Military Medical Research, 2025, 12(12): 1845-1859. DOI: 10.1186/s40779-025-00620-4.

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Related Author

Kui-Ying Yin
Tao Yu
邓艳春
李宁秀

Related Institution

Department of Neurology
Xijing Hospital
Fourth Military Medical University
Department of Clinical Epidemiology
First Affiliated Hospital
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