Epileptic seizure biophysics: the role of local voltage difference
RESEARCH|Updated:2026-01-27
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Epileptic seizure biophysics: the role of local voltage difference
“Reporting on the latest research in epilepsy, a neurological disorder marked by recurrent seizures, experts have delved into the bio-physical mechanisms of epileptic seizures. By analyzing spontaneous and stimulation-induced seizures from patients with focal epilepsy, they isolated the slow-varying direct current (Sv DC) component, a frequency range often overlooked in electroencephalography. This component, which accounts for a high energy proportion in both ictal and interictal states, showed spatially dynamic changes and a moderate correlation with high-frequency activity. Notably, interictal Sv DC fluctuations were more pronounced in electrodes within the epileptogenic zone, suggesting its potential as a marker for epileptogenic localization. The temporal variability of the Sv DC signal also demonstrates potential as an early indicator of seizure development. This research provides a comprehensive framework for understanding epileptic networks and guiding diagnosis and therapy.”
Military Medical ResearchVol. 12, Issue 12, Pages: 1845-1859(2025)
Affiliations:
1.Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China
2.Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
Kui-Ying Yin, Tao Yu, Chuan Liu, et al. Epileptic seizure biophysics: the role of local voltage difference[J]. Military Medical Research, 2025, 12(12): 1845-1859.
DOI:
Kui-Ying Yin, Tao Yu, Chuan Liu, et al. Epileptic seizure biophysics: the role of local voltage difference[J]. Military Medical Research, 2025, 12(12): 1845-1859. DOI: 10.1186/s40779-025-00620-4.
Epileptic seizure biophysics: the role of local voltage difference