Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis

Yue-Jie Xu; Cai-Zhi Liu; Ying Chen; Lan-Xin Li; Bo Xu; Ling-Xin You; Mei-Yao Meng; Xin Li; Hong Zhang; Qiu-Rong Ding; Rong Zhang; Xin-Ran Ma; Xiao-Hua Chen; Cheng Hu

doi:10.1186/s40779-025-00618-y

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Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis

RESEARCH | Updated：2026-01-27

- Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis
- “In the field of acute liver injury (ALI) research, experts have identified a molecular mechanism that initiates and sustains liver regeneration through muscle-liver crosstalk via the FGF6-FGFBP1/FGF5 axis, providing a potential therapeutic target and treatment strategy for ALI.”
- Military Medical Research Vol. 12, Issue 12, Pages: 1860-1882(2025)
- Affiliations：
  
  1.Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
  2.Jinzhou Medical University Graduate Training Base (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine), Jinzhou 121001, Liaoning, China
  3.Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
  4.Research Direction of New Microecological Technology, Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250000, China
  5.CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
  6.Department of Infectious Diseases, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
  7.Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai 201499, China
- Author bio：
  
  * Cai-Zhi Liu adaica@sjtu.edu.cn
  Xiao-Hua Chen chenxiaohua2000@163.com
  Cheng Hu alfredhc@sjtu.edu.cn
- Funds：
- DOI：10.1186/s40779-025-00618-y
  CLC：
- Received：23 December 2024，
  
  Accepted：28 May 2025，
  
  Online First：21 July 2025，
  
  Published：2025-12
- Accepted：
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Yue-Jie Xu, Cai-Zhi Liu, Ying Chen, et al. Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis[J]. Military Medical Research, 2025, 12(12): 1860-1882.
DOI：

Yue-Jie Xu, Cai-Zhi Liu, Ying Chen, et al. Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis[J]. Military Medical Research, 2025, 12(12): 1860-1882. DOI： 10.1186/s40779-025-00618-y.

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Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis

DOI：10.1186/s40779-025-00618-y