Diagnostic efficacy of fecal-based miR-92a for advanced colorectal neoplasia: a prospective multicenter screening trial
RESEARCH|Updated:2026-01-27
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Diagnostic efficacy of fecal-based miR-92a for advanced colorectal neoplasia: a prospective multicenter screening trial
“In a prospective multicenter screening trial, miR-92a demonstrated better sensitivity, NNS, Youden index and AUC as compared with FIT for advanced colorectal neoplasia screening. Using miR-92a appears to be more efficient for population-based screening programs, and screening sensitivity can be further enhanced if conditionally used in combination with FIT.”
Military Medical ResearchVol. 12, Issue 11, Pages: 1722-1734(2025)
Affiliations:
1.Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2.Department of Health Management, Shenzhen People’s Hospital, the Second Clinical Medical College of Jinan University/the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518053, Guangdong, China
3.Department of Gastrointestinal Surgery, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300000, China
4.Department of Gastroenterology, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Shenzhen 518020, Guangdong, China
5.Department of Nursing, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300000, China
6.Department of Gastroenterology, Shenzhen People’s Hospital, the Second Clinical Medical College of Jinan University/the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518053, Guangdong, China
7.Clinical Medical Research Center, Shenzhen People’s Hospital, the Second Clinical Medical College of Jinan University/the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518053, Guangdong, China
8.Shen-zhen Center for Chronic Disease Control, Shenzhen 518081, Guangdong, China
9.College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518000, Guangdong, China
10.Tianjin Third Central Hospital, Tianjin Medical University, Tianjin 300192, China
11.Tianjin Third Central Hospital, Nankai University, Tianjin 300192, China
12.Tianjin Third Central Hospital, Tianjin University, Tianjin 300192, China
Jia-Chen Wang, Li Zhao, Xiang-Yang Yu, et al. Diagnostic efficacy of fecal-based miR-92a for advanced colorectal neoplasia: a prospective multicenter screening trial[J]. Military Medical Research, 2025, 12(11): 1722-1734.
DOI:
Jia-Chen Wang, Li Zhao, Xiang-Yang Yu, et al. Diagnostic efficacy of fecal-based miR-92a for advanced colorectal neoplasia: a prospective multicenter screening trial[J]. Military Medical Research, 2025, 12(11): 1722-1734. DOI: 10.1186/s40779-025-00613-3.
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Office of Cancer Screening, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
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