Age-stratified associations between radiotherapy and SPMs for FPHNC:a population-based cohort study

Yuan-Yuan Li; Qiong Liu; Si-Qi Ying; Xiu-Quan Wu; Xiao-Hui Zhang; Xiao-Mei Xie; Bing-Dong Sui; Yan Jin; Yang Jiao; Franklin R. Tay

doi:10.1186/s40779-025-00612-4

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Age-stratified associations between radiotherapy and SPMs for FPHNC:a population-based cohort study

RESEARCH | Updated：2026-01-27

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- Age-stratified associations between radiotherapy and SPMs for FPHNC:a population-based cohort study
- “In a recent study, researchers investigated the age-stratified association between radiotherapy and the risk of second primary malignancies in head and neck cancer patients. The findings highlight the importance of considering patient age when making treatment decisions for head and neck cancer and suggest that long-term surveillance is necessary for high-risk groups.”
- Yuan-Yuan Li , Qiong Liu , Si-Qi Ying , Xiu-Quan Wu , Xiao-Hui Zhang , Xiao-Mei Xie , Bing-Dong Sui , Yan Jin , Yang Jiao , Franklin R. Tay
- Military Medical Research Vol. 12, Issue 11, Pages: 1673-1685(2025)
- Affiliations：
  1.State Key Laboratory of Oral and Maxillofacial Reconstruction and Regenera-tion, National Clinical Research Center for Oral Diseases, Shaanxi Key Labora-tory of Stomatology, Department of Prosthodontics, School of Stomatology, the Fourth Military Medical University, Xi’an 710032, China
  2.Department of General Dentistry, Xiamen University Affiliated Chenggong Hospital, the 73rd Army Hospital of Chinese PLA, Xiamen 361001, Fujian, China
  3.State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, the Fourth Military Medical University, Xi’an 710032, China
  4.Department of Orthopedics, Xijing Hospital, the Fourth Military Medical University, Xi’an 710032, China
  5.Department of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi’an 710032, China
  6.State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, the Fourth Military Medical University, Xi’an 710032, China
  7.Department of Stomatology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China
  8.Department of Endodontics, the Dental College of Georgia, Augusta University, Augusta, GA 30912-1129, USA
- Author bio：
  * Yuan-Yuan Li yuanyuanli1@fmmu.edu.cn
  Yang Jiao jiaoyang1989731@163.com
  Franklin R. Tay ftay@augusta.edu
- Funds：
- DOI： 10.1186/s40779-025-00612-4
  CLC：
- Accepted：28 April 2025 ，
- Accepted：
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Age-stratified associations between radiotherapy and SPMs for FPHNC:a population-based cohort study

DOI： 10.1186/s40779-025-00612-4

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