Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism
RESEARCH|Updated:2026-01-27
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Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism
“In the field of metabolic disorders, researchers have made significant progress. Experts have established the causal mechanism of social jetlag-induced fatty liver, which provides a new direction for treating metabolic dysfunction-associated steatotic liver disease.”
Military Medical ResearchVol. 12, Issue 11, Pages: 1703-1721(2025)
Affiliations:
1.Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
2.Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing 210008, China
3.National Key Laboratory for Novel Software Technology and the National Institute of Healthcare Data Science, Nanjing University, Nanjing 210008, China
Peng-Zi Zhang, Ying-Huan Shi, Yu-Xin Guo, et al. Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism[J]. Military Medical Research, 2025, 12(11): 1703-1721.
DOI:
Peng-Zi Zhang, Ying-Huan Shi, Yu-Xin Guo, et al. Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism[J]. Military Medical Research, 2025, 12(11): 1703-1721. DOI: 10.1186/s40779-025-00609-z.
Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism