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High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation
RESEARCH | Updated：2025-12-13
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    • High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation

    • “In the field of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), experts have verified the conjecture that high-salt diet (HSD) consumption promotes the differentiation of CD4+ T cells to proinflammatory T helper 17 (Th17) cells, which aggravates CP/CPPS. This finding provides a potential therapeutic target for CP/CPPS.”
    • Jing Chen , Rui Feng , Bin-Bin Gong , Wei-Kang Wu , Bang-Shun Dai , Rui Tan , Wen-Long Xu , Tong Meng , Xiao-Bin Wang , Yun-Zheng Xiao , Cheng Yang , Li Zhang , Chao-Zhao Liang
    • Military Medical Research Vol. 12, Issue 10, Pages: 1501-1519(2025)

    • DOI： 10.1186/s40779-025-00607-1     

      CLC：

    • Accepted：11 April 2025 ，

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