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Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies
REVIEW | Updated：2025-12-13
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    • Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies

    • “In the field of bone research, this paper reviews the connection between the nervous system and bone metabolism, either intact or after injury. It explores the relationship between specific brain nuclei and bone homeostasis, the characteristics of bone innervation and nerve subtypes, and the molecular features and regulatory functions of these nerves. The paper also summarizes available translational approaches that utilize nerve function to improve bone homeostasis and promote bone regeneration.”
    • Tong-Zhou Liang , Zhe-Yu Jin , Yue-Jun Lin , Zi-Yi Chen , Ye Li , Jian-Kun Xu , Fan Yang , Ling Qin
    • Military Medical Research Vol. 12, Issue 10, Pages: 1645-1666(2025)

    • DOI： 10.1186/s40779-025-00600-8     

      CLC：

    • Accepted：04 March 2025 ，

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Related Author

Ling Qin
Fan Yang
Jian-Kun Xu
Shan-Shan Zhang
Ruo-Qi Li
Zhong Chen
Xiao-Ying Wang
Aaron S. Dumont

Related Institution

School of Basic Medical Sciences, Zhejiang Chinese Medical University
Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, Zhejiang Chinese Medical University
Clinical Neuroscience Research Center, Department of Neurosurgery and Neurology, Tulane University School of Medicine
School of Clinical Medicine, University of Cambridge
Shengli Clinical College of Fujian Medical University; Department of Neurology, Fujian Provincial Hospital