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Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway
RESEARCH | Updated：2025-12-13
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    • Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway

    • “In the field of sepsis-induced acute lung injury, a novel pathway has been unveiled. Expert research demonstrates that lactate accumulation during sepsis promotes macrophage-derived extracellular CIRP release, which mediates ZBP1-dependent pulmonary vascular endothelial cell PANoptosis, exacerbating ALI. This finding offers new insights into the molecular mechanisms driving sepsis-related pulmonary complications and provides potential new therapeutic strategies.”
    • Ting Gong , Qing-De Wang , Patricia A. Loughran , Yue-Hua Li , Melanie J. Scott , Timothy R. Billiar , You-Tan Liu , Jie Fan
    • Military Medical Research Vol. 12, Issue 7, Pages: 1023-1045(2025)

    • DOI： 10.1186/s40779-024-00574-z     

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