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Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial
RESEARCH | Updated：2025-12-13
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    • Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial

    • “In the field of cardiovascular surgery, a phase 3 trial of tetracosactide (TCS10) targeting melanocortin receptors (MCRs) demonstrated significant improvement in 30-day mortality and reduced blood transfusion episodes. Expert sensitivity analysis using the Naïve Bayes classifier and density-based sensitivity index provides a new direction for improving surgical rescue outcomes in critically ill patients.”
    • Giorgio Noera , Alfio Bertolini , Laura Calzà , Mercedes Gori , Annalisa Pitino , Graziella D’Arrigo , Colin Gerard Egan , Giovanni Tripepi
    • Military Medical Research Vol. 12, Issue 6, Pages: 836-851(2025)

    • DOI： 10.1186/s40779-024-00555-2     

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