“In the field of interventional therapy for vascular malformations, a novel radiopaque ethanol injection (REI) has been developed to address the radiolucency issue of absolute ethanol. Expert research team mixed iopromide with ethanol to achieve radiopacity and improve the physicochemical properties of the solution. The REI has been tested in vivo and clinically, demonstrating safety, therapeutic effects, and compensation for the radiolucency of ethanol. This study lays a foundation for the construction of a safer and more effective interventional therapy system.”