Bone-organ axes: bidirectional crosstalk

An-Fu Deng; Fu-Xiao Wang; Si-Cheng Wang; Ying-Ze Zhang; Long Bai; Jia-Can Su

doi:10.1186/s40779-024-00540-9

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Bone-organ axes: bidirectional crosstalk

REVIEW | Updated：2025-12-13

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- Bone-organ axes: bidirectional crosstalk
- “Reporting on the latest research, this review delves into the bidirectional communication between bone and various organs, with a spotlight on osteokines and the role of extracellular vesicles in bone-organ interactions. It lays a foundation for developing physiologically relevant in vitro models and offers insights into bone-organ axis-related diseases.”
- An-Fu Deng , Fu-Xiao Wang , Si-Cheng Wang , Ying-Ze Zhang , Long Bai , Jia-Can Su
- Military Medical Research Vol. 12, Issue 4, Pages: 600-632(2025)
- Affiliations：
  1.Institute of Translational Medicine, Organoid Research Center, Shanghai University, Shanghai 200444, China
  2.National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China
  3.Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai 200444, China
  4.Department of Orthopaedics, the Third Hospital of Hebei Medical University, Orthopaedic Research Institution of Hebei Province, NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang 050051, China
  5.School of Medicine, Shanghai University, Shanghai 200444, China
  6.Wenzhou Institute of Shanghai University, Wenzhou 325000, Zhejiang, China
  7.Department of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
- Author bio：
  *yzzhang@hebmu.edu.cn;
  bailong@shu.edu.cn;
  jiacansu@shu.edu.cn
- Funds：
- DOI： 10.1186/s40779-024-00540-9
  CLC：
- Accepted：
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Bone-organ axes: bidirectional crosstalk

DOI： 10.1186/s40779-024-00540-9

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