Advancing skeletal health and disease research with single-cell RNA sequencing

Peng Lin; Yi-Bo Gan; Jian He; Si-En Lin; Jian-Kun Xu; Liang Chang; Li-Ming Zhao; Jun Zhu; Liang Zhang; Sha Huang; Ou Hu; Ying-Bo Wang; Huai-Jian Jin; Yang-Yang Li; Pu-Lin Yan; Lin Chen; Jian-Xin Jiang; Peng Liu

doi:10.1186/s40779-024-00538-3

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Advancing skeletal health and disease research with single-cell RNA sequencing

REVIEW | Updated：2025-12-13

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- Advancing skeletal health and disease research with single-cell RNA sequencing
- “In the field of orthopedics, a comprehensive review presents a streamlined approach to obtaining high-quality single cells from skeletal tissue and provides an overview of existing single-cell RNA sequencing technologies employed in skeletal studies along with practical bioinformatic analysis pipelines. This research has paved the way for discovering novel therapeutic targets that offer potential benefits to patients suffering from diverse skeletal disorders.”
- Peng Lin , Yi-Bo Gan , Jian He , Si-En Lin , Jian-Kun Xu , Liang Chang , Li-Ming Zhao , Jun Zhu , Liang Zhang , Sha Huang , Ou Hu , Ying-Bo Wang , Huai-Jian Jin , Yang-Yang Li , Pu-Lin Yan , Lin Chen , Jian-Xin Jiang , Peng Liu
- Military Medical Research Vol. 12, Issue 2, Pages: 285-310(2025)
- Affiliations：
  1.Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China
  2.Pancreatic Injury and Repair Key Laboratory of Sichuan Province, the General Hospital of Western Theater Command, Chengdu 610031, China
  3.Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR 999077, China
  4.Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Sacramento, CA 94305, USA
  5.Center of Bone Metabolism and Repair, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Laboratory for the Prevention and Rehabilitation of Military Training Related Injuries, Daping Hospital, Army Medical University, Chongqing 400042, China
  6.Wound Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China
- Author bio：
  *jiangjx@cta.cq.cn;
  liupengd@tmmu.edu.cn
- Funds：
- DOI： 10.1186/s40779-024-00538-3
  CLC：
- Accepted：
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Advancing skeletal health and disease research with single-cell RNA sequencing

DOI： 10.1186/s40779-024-00538-3

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