Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

Hui-Yang Lei; Gui-Lin Pi; Ting He; Rui Xiong; Jing-Ru Lv; Jia-Le Liu; Dong-Qin Wu; Meng-Zhu Li; Kun Shi; Shi-Hong Li; Na-Na Yu; Yang Gao; Hui-Ling Yu; Lin-Yu Wei; Xin Wang; Qiu-Zhi Zhou; Pei-Lin Zou; Jia-Yang Zhou; Ying-Zhou Liu; Nai-Ting Shen; Jie Yang; Dan Ke; Qun Wang; Gong-Ping Liu; Xi-Fei Yang; Jian-Zhi Wang; Ying Yang

doi:10.1186/s40779-024-00512-z

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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

RESEARCH | Updated：2025-02-24

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- Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
- “In the field of Alzheimer's disease research, this study elucidates distinct protein and phosphoprotein networks between dorsal and ventral hippocampal CA1 regions, highlighting the susceptibility of the vCA1 microcircuit to AD-like tau accumulation. Notably, the efficacy of ursolic acid in reducing tau load and targeting the vCA1 microcircuit may provide a promising strategy for treating AD in the future.”
- Hui-Yang Lei , Gui-Lin Pi , Ting He , Rui Xiong , Jing-Ru Lv , Jia-Le Liu , Dong-Qin Wu , Meng-Zhu Li , Kun Shi , Shi-Hong Li , Na-Na Yu , Yang Gao , Hui-Ling Yu , Lin-Yu Wei , Xin Wang , Qiu-Zhi Zhou , Pei-Lin Zou , Jia-Yang Zhou , Ying-Zhou Liu , Nai-Ting Shen , Jie Yang , Dan Ke , Qun Wang , Gong-Ping Liu , Xi-Fei Yang , Jian-Zhi Wang , Ying Yang
- Military Medical Research Vol. 12, Issue 1, Pages: 48-71(2025)
- Affiliations：
  1.Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  2.Department of Traditional Chinese Medicine, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China
  3.Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, China
  4.Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226000, Jiangsu, China
- Author bio：
  *wangjz@mail.hust.edu.cn;
  yingyang@hust.edu.cn
- Funds：
- DOI： 10.1186/s40779-024-00512-z
  CLC：
- Accepted：
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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

DOI： 10.1186/s40779-024-00512-z

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