BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

Yu Meng; Hui-Yan Sun; Yi He; Qian Zhou; Yi-Huang Liu; Hui Su; Ming-Zhu Yin; Fu-Rong Zeng; Xiang Chen; Guang-Tong Deng

doi:10.1186/s40779-023-00497-1

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BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

LETTER TO THE EDITOR | Updated：2025-12-13

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- BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition
- “In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, they have provided solutions to address xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.”
- Yu Meng , Hui-Yan Sun , Yi He , Qian Zhou , Yi-Huang Liu , Hui Su , Ming-Zhu Yin , Fu-Rong Zeng , Xiang Chen , Guang-Tong Deng
- Military Medical Research Vol. 11, Issue 4, Pages: 620-624(2024)
- Affiliations：
  1.Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
  2.National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha 410008, China
  3.Furong Laboratory, Changsha 410008, China
  4.Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha 410008, China
  5.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008, China
  6.Department of Breast Reconstruction, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300202, China
  7.Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
- Author bio：
  Yu Meng, Hui-Yan Sun and Yi He contributed equally to this work
  *zengflorachn@hotmail.com;
  chenxiangck@126.com;
  dengguangtong@outlook.com
- Funds：
- DOI： 10.1186/s40779-023-00497-1
  CLC：
- Accepted：
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BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

DOI： 10.1186/s40779-023-00497-1

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