Targeting NR1D1 in organ injury: challenges and prospects

Zi-Yin Zhang-Sun; Xue-Zeng Xu; Germaine Escames; Wang-Rui Lei; Lin Zhao; Ya-Zhe Zhou; Ye Tian; Ya-Nan Ren; Darío Acuña-Castroviejo; Yang Yang

doi:10.1186/s40779-023-00495-3

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Targeting NR1D1 in organ injury: challenges and prospects

REVIEW | Updated：2025-12-13

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- Targeting NR1D1 in organ injury: challenges and prospects
- “Nuclear receptor NR1D1, a key transcription factor in the circadian clock, plays a crucial role in regulating downstream target genes involved in autophagy, immunity, inflammation, metabolism, and aging. This review highlights the latest milestones in NR1D1 ligand research, which may pave the way for their clinical application in treating diverse organ injury-related diseases.”
- Zi-Yin Zhang-Sun , Xue-Zeng Xu , Germaine Escames , Wang-Rui Lei , Lin Zhao , Ya-Zhe Zhou , Ye Tian , Ya-Nan Ren , Darío Acuña-Castroviejo , Yang Yang
- Military Medical Research Vol. 11, Issue 6, Pages: 887-906(2024)
- Affiliations：
  1.Department of Cardiology, Northwest University First Hospital, Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, China
  2.Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, China
  3.Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, China
  4.Biomedical Research Center, Department of Physiology, Faculty of Medicine, Institute of Biotechnology, Technological Park of Health Sciences, University of Granada, 18016 Granada, Spain
  5.Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Ibs.Granada, San Cecilio University Hospital, 18016 Granada, Spain
  6.UGC of Clinical Laboratories, San Cecilio Clinical University Hospital, 18016 Granada, Spain
- Author bio：
  *dacuna@ugr.es;
  yang200214yy@nwu.edu.cn
- Funds：
- DOI： 10.1186/s40779-023-00495-3
  CLC：
- Accepted：
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Targeting NR1D1 in organ injury: challenges and prospects

DOI： 10.1186/s40779-023-00495-3

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