Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases

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Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases

REVIEW | Updated：2025-12-13

- Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases
- “Reporting on the latest research, experts have integrated up-to-date findings on endoplasmic reticulum stress in the pathogenesis of degenerative musculoskeletal diseases, laying a foundation for the construction of ER stress modulators in clinical trials.”
- Ze-Qin Wen , Jun Lin , Wen-Qing Xie , Yun-Han Shan , Ge-Hua Zhen , Yu-Sheng Li
- Military Medical Research Vol. 11, Issue 6, Pages: 839-862(2024)
- Affiliations：
  1.Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008, China
  2.Xiangya School of Medicine, Central South University, Changsha 410013, China
  3.Department of Orthopaedics, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou 215001, China
  4.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
  5.Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
  6.Department of Orthopaedic Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
- Author bio：
  *gzhen1@jhmi.edu;
  liyusheng@csu.edu.cn
- Funds：
- DOI： 10.1186/s40779-023-00485-5
  CLC：
- Accepted：
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