RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

RESEARCH | Updated：2025-12-13

- RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer
- “In the field of triple negative breast cancer brain metastasis, researchers have identified and verified the specific down-regulation of retinoic acid receptor responder 2 (RARRES2) in brain metastasis of TNBC. The study found that RARRES2 deficiency promotes BCBrM through lipid metabolic reprogramming, providing potential biomarkers or therapeutic targets for BCBrM.”
- Yi-Qun Li , Fang-Zhou Sun , Chun-Xiao Li , Hong-Nan Mo , Yan-Tong Zhou , Dan Lv , Jing-Tong Zhai , Hai-Li Qian , Fei Ma
- Military Medical Research Vol. 11, Issue 1, Pages: 34-49(2024)
- Affiliations：
  1.Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  2.State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Author bio：
  * qianhaili@pumc.edu.cn,
  mafei@cicams.ac.cn
- Funds：
- DOI： 10.1186/s40779-023-00470-y
  CLC：
- Accepted：
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