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Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function
RESEARCH | Updated：2024-01-23
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    • Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function

    • “On January 23, 2024, a team of experts led by Guo-Sheng Wu, Zhao-Fan Xia from the School of Department of Burn SurgeryandRen-Qi Yao, Yong-Ming Yao from the School of Translational Medicine Research Centerpublished an article in the MMR, introduces its research progress in the field of sepsis immunotherapy. Experts identified HLA-DRlowS100Ahigh monocytes driving immunosuppression and verified S100A9 blockade reverses immune depression, providing a novel therapeutic strategy for sepsis management.”
    • Ren-Qi Yao , Peng-Yue Zhao , Zhi-Xuan Li , Yu-Yang Liu , Li-Yu Zheng , Yu Duan , Lu Wang , Rong-Li Yang , Hong-Jun Kang , Ji-Wei Hao , Jing-Yan Li , Ning Dong , Yao Wu , Xiao-Hui Du , Feng Zhu , Chao Ren , Guo-Sheng Wu , Zhao-Fan Xia , Yong-Ming Yao
    • Military Medical Research Vol. 10, Issue 6, Pages: 778-797(2023)

    • DOI： 10.1186/s40779-023-00462-y     

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Related Author

Guillaume Monneret
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Related Institution

Hospices Civils de Lyon, Immunology Laboratory, Hôpital E. Herriot
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Department of Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University
Translational Medicine Research Center, Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital
Ludwig-Boltzmann Institute for Experimental and Clinical Traumatology