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Aspartoacylase suppresses prostate cancer progres-sion by blocking LYN activation
RESEARCH | Updated：2025-12-13
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    • Aspartoacylase suppresses prostate cancer progres-sion by blocking LYN activation

    • “Reporting on a breakthrough in prostate cancer research, a study at Zhongnan Hospital of Wuhan University identifies aspartoacylase (ASPA) as a novel inhibitor of disease progression. The research, which involved advanced transcriptomic methodologies and comprehensive in vitro and in vivo assays, found that ASPA's decreased expression is associated with poor patient prognosis and that its activity suppresses cancer cell proliferation and metastasis. The study reveals ASPA's direct interaction with LYN, inhibiting its phosphorylation and downstream signaling, offering a new direction for prostate cancer management.”
    • Hong Weng , Kang-Ping Xiong , Wang Wang , Kai-Yu Qian , Shuai Yuan , Gang Wang , Fang Yu , Jun Luo , Meng-Xin Lu , Zhong-Hua Yang , Tao Liu , Xing Huang , Hang Zheng , Xing-Huan Wang
    • Military Medical Research Vol. 11, Issue 2, Pages: 180-205(2024)

    • DOI： 10.1186/s40779-023-00460-0     

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