Applications and prospects of cryo-EM in drug discovery

Kong-Fu Zhu; Chuang Yuan; Yong-Ming Du; Kai-Lei Sun; Xiao-Kang Zhang; Horst Vogel; Xu-Dong Jia; Yuan-Zhu Gao; Qin-Fen Zhang; Da-Ping Wang; Hua-Wei Zhang

doi:10.1186/s40779-023-00446-y

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Applications and prospects of cryo-EM in drug discovery

REVIEW | Updated：2023-04-26

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- Applications and prospects of cryo-EM in drug discovery
- “On April 26, 2023, a team of experts led by Kong-Fu Zhu, Da-Ping Wang, Hua-Wei Zhang from the School of Department of Biomedical Engineering published an article in the MMR, introduces cryo-EM accelerating drug discovery. Experts overviewed cryo-EM applications in structure-based design and AI integration, opening new directions for pharmaceutical innovation.”
- Kong-Fu Zhu , Chuang Yuan , Yong-Ming Du , Kai-Lei Sun , Xiao-Kang Zhang , Horst Vogel , Xu-Dong Jia , Yuan-Zhu Gao , Qin-Fen Zhang , Da-Ping Wang , Hua-Wei Zhang
- Military Medical Research Vol. 10, Issue 6, Pages: 848-861(2023)
- Affiliations：
  1.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China
  2.Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
  3.Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
  4.Center for Protein Science and Crystallography, School of Life Sciences, Faculty of Science, Chinese University of Hong Kong, Hong Kong 999077, China
  5.Interdisciplinary Center for Brain Information, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
  6.Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
  7.Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, Guangdong, China
  8.Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
  9.State Key Lab for Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China
  10.Cryo-EM Facility Center, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China
  11.Department of Orthopedics, Shenzhen Intelligent Orthopaedics and Biomedical Innovation Platform, Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518000, Guangdong, China
  12.Guangdong Provincial Key Laboratory of Advanced Biomaterials, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China
- Author bio：
  *: wangdp@mail.sustech.edu.cn;
  zhanghw@sustech.edu.cn
- Funds：
- DOI： 10.1186/s40779-023-00446-y
  CLC：
- Accepted：
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Applications and prospects of cryo-EM in drug discovery

DOI： 10.1186/s40779-023-00446-y

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